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Orakpo, a star and two-time Pro Bowler, toe the pectoral muscle near his left shoulder during the 31-28 loss. Carriker tore his quad tendon in his right knee.
These are two big losses for the Redskins defense, who could use some help or for someone to step up as they begin a new era led by quarterback Robert Griffin III.
"It's an opportunity for somebody else now," linebacker London Fletcher said. "We're a no-excuse football team."
We'll see how Washington moves forward now with this big loss.
Josh Dhani is the founder of FootBasket. You can read more about him at his website. Follow him on Twitter @joshdhani.